Work packages
WP1 Data collection and annotation
WP1 focuses on establishing the data foundation required for the project by defining a robust data management plan and setting up the necessary data-sharing agreements. It supports the creation of a centralized database containing the medical images and clinical data required across the project, while enabling structured data curation and annotation workflows. As part of this work, a dedicated annotation tool compatible with spectral DICOM images is developed to ensure consistent and high-quality data labeling.
All data handling, storage, and sharing activities are carried out in full compliance with applicable agreements, ethical requirements, and data protection legislation, ensuring secure and lawful use of clinical and imaging data throughout the project.
WP2 Spectral Imaging for the precise oncological intervantion
WP2 focuses on the technical development of spectral cone-beam CT (CBCT) and the enhancement of spectral CT for interventional oncology, alongside the clinical evaluation of the resulting solutions. The work addresses key limitations of dual-scan spectral CBCT by compensating for motion and reducing noise and artefacts, while assessing its added value for oncological interventions. It also advances spectral CBCT X-ray detection through the development of a dual-layer detector and an improved anti-scatter grid. In parallel, spectral CT image quality for interventional procedures is enhanced using AI-based methods to reduce noise, improve spatial resolution, and mitigate motion- and metal-related artefacts, with a systematic evaluation of the associated clinical benefits.
The developed solutions are primarily intended for research and evaluation purposes and will not be released for clinical use within the project timeframe. Clinical partners will assess them offline and retrospectively using data acquired through the project’s clinical studies, or through phantom studies for the CBCT X-ray detection developments.
WP3 Workflow for spectral-guided IO procedures
WP3 focuses on expanding the capabilities of the Epione robotic solution to support spectral CT and spectral CBCT–guided procedures in interventional oncology. The work includes identifying and creating synergies between the robotic system and electrochemotherapy equipment, as well as optimizing image acquisition protocols and procedural workflows to enable efficient interventions and reliable treatment assessment, ultimately supporting good clinical outcomes.
The expanded workflows are evaluated using phantom-based studies to assess performance and identify opportunities for optimization, including improvements in room layout and procedural steps. These evaluations aim to refine both technical integration and clinical workflow efficiency before translation to clinical practice.
WP4 Spectral biomarker
WP4 focuses on the evaluation of potential imaging biomarkers derived from spectral maps generated during interventional procedures. Despite the availability of advanced treatment tools, current clinical endpoints remain limited and often rely on follow-up imaging to assess treatment efficacy. By exploiting the multiparametric information provided by spectral CT and spectral CBCT, this work aims to extract per-treatment insights that could help predict treatment effectiveness and support strategy adaptation during the procedure itself.
The work represents an initial step in biomarker development by investigating potential associations between parameters derived from spectral maps and early as well as late clinical outcomes. These exploratory analyses are intended to lay the foundation for future, more refined biomarkers that can improve intra-procedural decision-making and treatment assessment.
WP5 Economic evaluation and group concept mapping in health
WP5 focuses on understanding and assessing the clinical adoption and economic impact of interventional oncology (IO) procedures. It examines the factors that may facilitate or hinder the uptake of IO treatments, such as thermal ablation and radioembolization, in routine clinical practice. In parallel, it conducts economic evaluations linked to all clinical studies within the project to assess the value of these procedures from a hospital perspective.
The work also includes a dedicated health economic evaluation of the Hora Est HCC 2 study over a six‑month period, extending the analysis to both hospital and payer perspectives. Together, these activities aim to provide evidence on clinical feasibility, adoption drivers, and economic performance to support informed decision-making by healthcare providers and stakeholders.
WP6 Dissemination, communication, and exploitation
WP6 focuses on defining and implementing a comprehensive strategy to disseminate, communicate, and exploit the Key Exploitable Results (KERs) generated by the PreciseOnco project. It aims to raise awareness among end users of the clinical benefits of spectral CT in interventional radiology and interventional oncology, while supporting the production of high‑impact scientific outputs such as publications, posters, and conference presentations. The work also promotes active stakeholder engagement to ensure broad visibility and relevance of project outcomes.
In parallel, the Work Package supports the development and promotion of evidence‑based recommendations on the value of spectral imaging across the oncology care pathway. It facilitates early and continuous engagement of patients, clinical decision‑makers, and other key stakeholders to encourage acceptance, informed decision‑making, and timely uptake of PreciseOnco results into clinical practice.
WP7 Project Management
WP1 focuses on the coordination and overall management of the PreciseOnco project in accordance with the Grant Agreement and the defined project plan. It ensures effective governance, day‑to‑day coordination, and alignment of project activities, while fostering cohesion across partners and enabling strong interdisciplinary collaboration throughout the consortium.
In parallel, the Work Package addresses project‑level risk management by continuously assessing potential risks and identifying mitigation measures at an early stage. This proactive approach is designed to safeguard timely progress, maintain project quality, and support the successful delivery of project objectives.